What is isotretinoin and how does it work?

Isotretinoin (brand name Roaccutane) is a type of Vitamin A and belongs to a group of drugs known as retinoids. 

It works to treat acne by controlling the production of sebum (an oily substance produced by the skin) and the production of keratin (outer scales of skin) that block the pores of the hair follicle.

It is licensed to treat severe acne, often where there is risk of scarring. However it may also be occasionally used to treat other skin conditions e.g. Hidradenitis Suppurativa and Rosacea.

It is best to take after a meal to aid absorption. About 9 out of 10 people see a significant improvement in their acne with just one single course of isotretinoin. A course of treatment usually lasts 4 to 6 months. However, the acne may worsen before it starts to improve. Only occasionally, a prolonged or further course of treatment is required. The benefits of isotretinoin can continue several years after treatment.

Also also recommend a range of Vitamin A supplements after you course of isotretinoin to reduce the change of acne relapse.

Pregnancy Prevention Programme

If a person becomes pregnant whilst taking isotretinoin or 4 weeks after they finish the course, there is a high risk that the baby will be harmed with severe and serious defects (such as abnormal appearance or intellectual disability) and an increased risk of miscarriage.

All women with child-bearing potential should be entered into the Pregnancy Prevention Programme whilst taking their course of isotretinoin, in order to

minimise the risk of pregnancy. There are rules that the government body, the Medicines and Healthcare products Regulatory Agency, has produced which doctors and pharmacists must follow.#AFmEAcBTmn#rXHJfAAwp4

Further details on side effects of isotretinoin can be found here. (Link to British Association Dermatologists Patient information leaflet)

Usual treatment duration is between 4-6 months, but this depends on the individual, and may be longer.

The total cost for a 4 month treatment (includes all tests *but does not include drug cost; they must be purchased from pharmacy: approx £50-60 per month) is approximately £620. 

It is not possible for your GP to prescribe Iostretninoin through the NHS.

Appointment 1: Assessment, blood tests, Pregnancy test (if applicable).   £160.

Appointment 2: (After 4 weeks): review, blood tests, Pregnancy test (if applicable).  £160.

Appointment 3: (After 4 weeks): Review. £100

Appointment 4 and subsequent appointments if needed: (After 4 weeks): Review. £100

Fees are payable at the time of each appointment.(So the cost of treatment and follow up is spread out over the 4-6 months).

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